A reconsideration of the somatic mutation theory of cancer in the light of some recent developments.
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منابع مشابه
Detection of Somatic Mutation in Exon 12 of DNA Polymerase β in Ovarian Cancer Tissue Samples
Background: DNA polymerase β (pol β) is a key enzyme of base excision repair pathway. It is a 1-kb gene consisting of 14 exons. Its catalytic part lies between exon 8 and exon 14. Exon 12 has a role in deoxyribonucleotide triphosphate selection for nucleotide transferase activity. Methods: Genomic DNA was isolated from ovarian carcinoma samples. Single strand conformation polymorphism...
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ورودعنوان ژورنال:
- Science
دوره 117 3043 شماره
صفحات -
تاریخ انتشار 1953